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The children have a lower percentage of the cases, and less severe illness courses. Some possible explanations, including the tendency to catch and occupy the upper airway. Also, the different expression of receptors of angiotensin-converting enzyme and renin–angiotensin system. A less vigorous immune response in children accounts for the less severity. In children, the lower …

 The interaction between COVID-19 and the immune system participates in the dysfunction of the immune responses and disease advancement. Antibodies against the spike protein could prevent COVID-19 from binding with the angiotensin – converting enzyme 2 (ACE2) receptor on host cells. Blocking ACE2 interaction could avoid the virus from infecting the host cell. The generation …

A radical is any molecule or atom that contains one or more unpaired electrons. Radicals are normal products of various metabolic pathways. Such interactions can cause both acute and chronic dysfunction, but can also provide essential control of redox regulated signaling pathways. The potential roles of endogenous or xenobiotic-derived free radicals in several human pathologies …

The main pulmonary finding was diffuse alveolar damage in the acute or organising phases, rendering focal pulmonary microthrombi. The primary pathology observed was diffuse alveolar damage, with virus existing in the pneumocytes and tracheal epithelium. Microthrombi were rare and endotheliitis was not identified. Immunohistochemistry staining was done on formalin fixed, paraffin-embedded 5-µm sections following citrate …

Powerful cytokine production in patients with SARS-CoV2-induced pneumonia gives a practical exhibition and explanation of medical intervention. Most patients with SARS-CoV-2 infection expanded mild symptoms, whereas some patients later developed more serious disease symptoms, and eventually died because of multiple organ dysfunction syndrome (MODS), as a result of a severe cytokine storm. The cytokine storm …